Optical Control of Mitochondrial Reactions Using C60

Purpose: This study explores how a molecule combining ferrocene (Fc), porphyrin (ZnP), and fullerene (C60) can be used with light to control chemical reactions in the mitochondria of living cells, specifically HeLa cells, to influence cell functions like signaling and biomolecule synthesis.

Findings: The Fc-ZnP-C60 molecule, delivered to mitochondria using a nano-carrier called MITO-Porter, triggers a light-activated electron transfer reaction. This produces a controlled release of reactive oxygen species (O2-) in the mitochondria, leading to programmed cell death (apoptosis). The C60 component enhances the molecule’s ability to efficiently manage this reaction due to its unique ability to hold and transfer electrons.

Relation to C60: Fullerene (C60), a soccer ball-shaped carbon molecule, is a key part of the Fc-ZnP-C60 system. Its structure allows it to support long-lasting electron transfer when activated by light, making it critical for precisely controlling mitochondrial reactions without invasive methods.

Implications for Consumers and Healthcare Professionals: This research suggests potential for non-invasive treatments using light and C60-based molecules to target cellular processes, such as in cancer therapy, where controlled cell death is desired. It could lead to precise medical tools that adjust cell functions with minimal side effects.

Conclusion: The study demonstrates that C60, as part of a light-activated system, is a promising tool for safely manipulating cell functions, but further research is needed to develop practical applications for medical use.

Link to Study