Carboxyfullerene SOD Mimetic Enhances Cognition and Lifespan in Mice

A groundbreaking study published in Neurobiology of Aging (Quick et al., 2006) explored the effects of a synthetic superoxide dismutase (SOD) mimetic, a small-molecule antioxidant, on aging in wild-type mice. Starting at middle age, mice received chronic treatment with a carboxyfullerene-based compound designed to combat oxidative stress by mimicking SOD’s ability to neutralize reactive oxygen species. The results were striking: treated mice not only lived significantly longer but also showed reduced age-related oxidative damage and mitochondrial radical production. Additionally, the mice performed better on the Morris water maze, a test of learning and memory, indicating preserved cognitive function. This study is the first to demonstrate that an antioxidant with mitochondrial activity and nervous system penetration can extend lifespan and reverse age-related cognitive decline in mammals. These findings suggest potential applications for SOD mimetics in addressing aging and cognitive health, offering a promising avenue for future research in humans.

Link to research Study