Liposome-Fullerene Complex Protects Skin from UVA Damage

A research study published in Biochemical and Biophysical Research Communications in 2010 by Ito et al. investigates the protective effects of a fullerene-C60/liposome complex (Liposome-Fullerene, or Lpsm-Flln) against skin damage caused by UVA radiation, a harmful component of sunlight. The study shows that this complex can shield skin from UVA-induced harm, making it a promising ingredient for skin care products.

In simple terms, UVA rays from the sun can damage skin by causing dryness, breaking down collagen (which keeps skin firm), and harming cell DNA, leading to aging or worse. The researchers applied Lpsm-Flln, a tiny particle mix of fullerene-C60 (a carbon molecule) and liposomes (fat-like carriers), to a 3D human skin model and human skin samples. Over four days, they exposed the skin to repeated UVA doses, mimicking sun exposure, while applying and rinsing off Lpsm-Flln. The results showed that Lpsm-Flln (at 250 ppm, with just 0.75 ppm of C60) significantly reduced skin scaling, collagen breakdown, and DNA damage compared to liposomes alone, which offered little protection.

Tests also showed that a small amount of C60 penetrated the outer skin layer (epidermis) but didn’t reach deeper layers or enter the bloodstream, suggesting it’s safe for cosmetic use. Building on research like Rud et al. (2012), which showed C60’s antiviral effects, this study highlights Lpsm-Flln’s potential as a safe, antioxidant ingredient in sunscreens or creams to protect skin from UVA damage and premature aging.

Link to research study