In this 2010 double-blind, human study, it was found that when applied topically, C60 was effective at reducing wrinkles. Fullerene is effective against wrinkles

• Study strengths: This double-blind study was done on humans and was the first human study showing the health benefits of topically applied C60.
• Study weaknesses: None.

C60 may be effective at combating hair loss. In this 2009 study, C60 was found to promote hair growth. Researchers believe it does this by protecting the cells around hair follicles from oxidative damage. Fullerene nanomaterials potentiate hair growth

• Study strengths: Topically applied C60 was shown to promote hair growth.
• Study weaknesses: However, C60 did not appear to stimulate inactive hair follicles.

In 2010, C60 was found to protect human skin cells against UV damage. Fullerene-C60/liposome complex: Defensive effects against UVA-induced damages in skin structure, nucleus and collagen type I/IV fibrils, and the permeability into human skin tissue

• Study strengths: C60 was shown to prevent the breakdown of collagen type I/IV, DNA strand cleavage, and pyknosis/karyorrhexis.
• Study weakness: This study was done with human skin cells in vitro, in a test tube.