C60 is characterized as a “free radical sponge” with an antioxidant efficacy several hundred-fold higher than conventional antioxidants. The Applications of Buckminsterfullerene C60 and Derivatives in Orthopedic Research

• Study strengths: This study reviewed a large number of previous research studies showing that C60 had beneficial effects in a wide range of applications.
• Study weakness: None.

C60 was found to be protective against free radical damage caused by induced toxins. C60 Carboxyfullerene Exerts a Protective Activity against Oxidative Stress-Induced Apoptosis in Human Peripheral Blood Mononuclear Cells

• Study strengths: C60 showed a strong protective effect.
• Study weaknesses: This study was done with human cells in vitro, in a test tube.