Carboxyfullerenes as Potent Neuroprotective Agents

A pioneering study published in the Proceedings of the National Academy of Sciences (Dugan et al., 1997) investigated the neuroprotective potential of water-soluble carboxylic acid C60 derivatives, specifically two regioisomers (C3 and D3 symmetry) with three malonic acid groups per molecule. Using electron paramagnetic resonance (EPR) analysis, both isomers demonstrated equipotent free radical scavenging in…